There is an opioid epidemic in the United States. According to the Health Resources and Services Administration (HRSA), opioid-related overdoses cause more than 130 deaths every day. Fortunately, there are non-opioid alternatives that are effective for managing chronic pain.. The aim of this network meta-analysis (NMA) was to evaluate the safety and efficacy of intravenous (IV) Meloxicam 30 mg (MIV), an investigational non-steroidal anti-inflammatory drug (NSAID), and certain other IV non-opioid analgesics for moderate-severe acute postoperative pain. We searched PubMed and CENTRAL for Randomized Controlled Trials (RCT) (years 2000-2019, adult human subjects) of.
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The Food and Drug Administration (FDA or Agency) is announcing the availability of a draft guidance for industry entitled "Development of Non-Opioid Analgesics for Acute Pain.". In connection.. The opioids decrease the brain's awareness of the pain, whereas the non-opioids affect some of the chemical changes that normally take place wherever body tissues are injured or damaged. These chemical changes at the site of the injury typically result in inflammation and increased pain sensitivity.
